By InvitationNot Applicable

The Correlation Between CT and MRCP Before Living Liver Donation for Liver Blood Vessel Assessment: an Ambidirectional Cohort Study

Netherlands90 participantsStarted 2026-01-01

Plain-language summary

Living donor liver transplantation (LDLT) is a good solution to the donor liver shortage in the Netherlands. In cases of severe liver disease, LDLT has substantial survival benefits, fewer (future) complications, and an improved quality of life. Donor screening is extensive to minimize risks for both donors and recipients. The liver's blood vessels are assessed using CT and the bile ducts with MRCP. Blood vessel assessment can also be performed using MRCP, which would make the CT unnecessary. Before CT can be removed from the screening procedure, the correlation between blood vessel assessment on CT and MRCP must be clarified. It is hypothesized that CT is equally adequate in assessing liver blood vessels to MRCP.

Who can participate

Age range18 Years – 60 Years

SexALL

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Inclusion Criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: * Living liver donation between May 2004 and June 2026 * Written informed consent In order to be eligible for LDLT, a subject needed to meet all of the following criteria: * 18-60 years old * Physical and mental well-being * Body Mass Index (BMI) \<33 kg/m2 * No active drugs or other substances use Exclusion Criteria: There are no exclusion criteria for this study. Exclusion criteria for LDLT were: Absolute exclusion criteria * Medical conditions (for instance heart disease and bleeding or clotting disorders) * History of liver disease * Previous/active malaria infection * Financial incentive or indications of pressure * Unable to cooperate with designated long-term follow-up * Severe psychiatric disease or psychological instability * Active alcoholism or frequent heavy alcohol use or drugs use/abuse * Unable to give informed consent * History of dementia or other neurological degenerative disorders * Persons with rabies or persons bitten in the past 6 months by an animal and that are treated as if the animal is rabid * Persons with syphilis * Human immunodeficiency virus-positive persons. Relative exclusion criteria * BMI \>33 kg/m2 * Smoking

What they're measuring

Essential blood vessels

Timeframe: Preoperative during screening for living liver donation.

Trial details

NCT IDNCT06875232

SponsorErasmus Medical Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-11-30