The Correlation Between CT and MRCP Before Living Liver Donation for Liver Blood Vessel Assessmen… (NCT06875232) | Clinical Trial Compass
By InvitationNot Applicable
The Correlation Between CT and MRCP Before Living Liver Donation for Liver Blood Vessel Assessment: an Ambidirectional Cohort Study
Netherlands90 participantsStarted 2026-01-01
Plain-language summary
Living donor liver transplantation (LDLT) is a good solution to the donor liver shortage in the Netherlands. In cases of severe liver disease, LDLT has substantial survival benefits, fewer (future) complications, and an improved quality of life.
Donor screening is extensive to minimize risks for both donors and recipients. The liver's blood vessels are assessed using CT and the bile ducts with MRCP. Blood vessel assessment can also be performed using MRCP, which would make the CT unnecessary. Before CT can be removed from the screening procedure, the correlation between blood vessel assessment on CT and MRCP must be clarified.
It is hypothesized that CT is equally adequate in assessing liver blood vessels to MRCP.
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
In order to be eligible to participate in this study, a subject must meet all of the following criteria:
* Living liver donation between May 2004 and June 2026
* Written informed consent
In order to be eligible for LDLT, a subject needed to meet all of the following criteria:
* 18-60 years old
* Physical and mental well-being
* Body Mass Index (BMI) \<33 kg/m2
* No active drugs or other substances use
Exclusion Criteria:
There are no exclusion criteria for this study.
Exclusion criteria for LDLT were:
Absolute exclusion criteria
* Medical conditions (for instance heart disease and bleeding or clotting disorders)
* History of liver disease
* Previous/active malaria infection
* Financial incentive or indications of pressure
* Unable to cooperate with designated long-term follow-up
* Severe psychiatric disease or psychological instability
* Active alcoholism or frequent heavy alcohol use or drugs use/abuse
* Unable to give informed consent
* History of dementia or other neurological degenerative disorders
* Persons with rabies or persons bitten in the past 6 months by an animal and that are treated as if the animal is rabid
* Persons with syphilis
* Human immunodeficiency virus-positive persons. Relative exclusion criteria
* BMI \>33 kg/m2
* Smoking
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Essential blood vessels
Timeframe: Preoperative during screening for living liver donation.