By InvitationNot Applicable

Outcomes of Empiric Antibiotic Therapy Based on Hospital Antibiograms in Organ Transplant Recipients with Bacteraemia

Italy150 participantsStarted 2024-12-03

Plain-language summary

The purpose of this observational study is to examine how using the hospital cumulative antibiogram to guide empirical antibiotic therapy affects outcomes in patients with bloodstream infections who have undergone solid organ transplants. The key question is: does the use of a hospital cumulative antibiogram reduce mortality and improve outcomes in these patients?

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥ 18 years * Being SOT * Monomicrobial bloodstream infection due to Acinetobacter baumannii, Enterobacter spp., Enterococcus faecalis, Enterococcus faecium, Escherichia coli, Klebsiella pneumoniae, Klebsiella other-than pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Serratia marcescens, Staphylococcus aureus, Staphylococcus lugdunensis, and Streptococcus spp. * Hospitalization in Fondazione IRCCS Cà Granda Policlinico of Milano from 2015 to 2023. Exclusion Criteria: * Antibiotic therapy administration outside 48h before-after blood culture collection. * Polymicrobial bloodstream infections.

What they're measuring

15-days mortality

Timeframe: 15 days from bloodstream infection

Trial details

NCT IDNCT06874920

SponsorFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-01-01

View on ClinicalTrials.gov More Bacteremia trials