Pronase in Improving Endoscopic Mucosal Clarity During Colonoscopy for Patients with Colitis

Inclusion Criteria: * Patients presenting with intestinal inflammation during colonoscopy, accompanied by mucus obscuring visualization, were included, particularly those with inflammatory bowel disease (IBD), regardless of the presence or absence of clinical symptoms such as abdominal pain, diarrhea, hematochezia, or mucoid stools. * Researchers assessed the current health status of potential participants to ensure they could tolerate colonoscopy (based on physical examination and medical history). * Age range was 18-75 years (inclusive). * Participants provided written informed consent to participate voluntarily. Exclusion Criteria: * Participants with known hypersensitivity or allergy to the study medication. * Participants with peritonitis, intestinal obstruction, severe intestinal infection, or radiation colitis. * Participants who did not exhibit intestinal mucus obscuring endoscopic visualization during colonoscopy. * Participants with severe cardiovascular, pulmonary, neurological, or renal disease, or those deemed unfit for colonoscopy. * Participants who did not provide written informed consent or lacked the capacity to do so. * Pregnant or breastfeeding women. * Participants who had taken antiplatelet medications (e.g., aspirin, clopidogrel) or had abnormal coagulation function within 7 days prior to colonoscopy. * Participants currently participating in other clinical observation trials or who had participated in another clinical trial within 60 days.