RecruitingNot Applicable

Comparison of Dairy and Plant-based Alternatives in Adolescents and Older Adults

Canada160 participantsStarted 2025-04-01

Plain-language summary

The purpose of the Dairy vs Plant study is to compare the effects of dairy and plant-based alternative products on blood sugar regulation and nutrient quality in adolescents and older adults. We are inviting healthy, non-diabetic participants aged 14-18 and 60-75, both males and females to participate. The study will take place in the Nutrition Intervention Center located at the Department of Nutritional Sciences, University of Toronto St. George campus. Participants will be asked to come to the Nutrition Intervention Center on 3 separate occasions: once for an in-person screening lasting approximately 30min and 2 times for study visits lasting approximately 2.5 hrs each. The entire study will take a minimum of 2 weeks to complete. You will be asked to fast for 12hrs (overnight) prior to each study visit. You will also be instructed to maintain the same dietary and sleep patterns, refrain from exercise and alcohol consumption the days before the study visits. During these study visits, you will be asked to consume either a dairy or a plant-based alternative product, as well as a pizza meal. You will periodically fill out questionnaires rating your feelings and perceptions and provide blood samples through finger pricks and intravenously through forearm to measure blood sugar, insulin, hormones, and amino acids. You will be compensated for your time and travel expenses.

Who can participate

Age range

14 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 14-18 years old (adolescents) or 60-75 years old (older adults) * BMI z-score \>+1SD, \<+2SD (adolescents) or BMI 25-30 kg/m2 (older adults) * Willing to maintain habitual diet, physical activity pattern, and body weight throughout the study. * Willing to maintain current dietary supplement use throughout the study. On study visit days, subject agrees not to take any supplements until dismissal from the Nutrition Intervention Center. * Willing to abstain from alcohol consumption for 24hrs prior to all study visits. * Willing to avoid vigorous physical activity for 24hrs prior to all study visits. * Willing to refrain from cannabis use throughout the entire duration of the study. * Willing to refrain from protein supplement use (e.g. protein powder) throughout the entire duration of the study. * Understands the study procedures, provides informed consent to participate in the study, and authorizes release of relevant protected health information to the study investigator. Exclusion Criteria: * Smoking * Thyroid problems * Lactose intolerance and/or allergies, intolerances, or sensitivities to study treatments * Previous history of cardiovascular disease, diabetes, liver or kidney disease, inflammatory bowel disease, celiac disease, short bowel syndrome, malabsorptive syndrome, pancreatitis, gallbladder or biliary disease * Presence of gastrointestinal disorder or surgeries within the past year. * Inability to comply with the experimental procedures…

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Blood glucose

Timeframe: Over 145 minutes after treatment consumption at each session, for a total of 2 weekly sessions.

Trial details

NCT IDNCT06874400

SponsorUniversity of Toronto

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-04-01

Contact for this trial

Corrina Zhou, MSc

416-946-3802 corrina.zhou@mail.utoronto.ca

View on ClinicalTrials.gov More Glycemic Response to Feeding in Healthy Participants trials