CompletedEarly Phase 1

Effect of Melatonin on Postoperative Pain After Simple Nephrectomy

Egypt40 participantsStarted 2025-03-21

Plain-language summary

The aim of the study is to evaluate the role of melatonin in the management of postoperative pain in patients undergoing simple nephrectomy regarding: * Pain score (VAS). * Total Morphine consumption is 1st 24 hr. * Time to the 1st rescue analgesia. * Intra-operative and post-operative hemodynamics. * Anxiety. * Patient satisfaction. * Adverse events.

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age from 18 to 65 years. * Both sexes. * (ASA) physical status I, II. * Patients undergoing simple nephrectomy. Exclusion Criteria: * Patient refusal. * Patients with a history of allergic reactions to melatonin. * Patients receiving drugs with known analgesic and sedative properties. * Body Mass Index (BMI) over 30 kg/m2. * Drug or alcohol abuse. * History of cardiovascular disease. * Renal Failure. * Mental impairment. * Renal impairment.

What they're measuring

Pain score (VAS) at 24 h postoperatively

Timeframe: 24 hours postoperative

Trial details

NCT IDNCT06872944

SponsorCairo University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-06-21

View on ClinicalTrials.gov More Pain Score (VAS) at 24 h Postoperatively trials