CompletedNot Applicable

Perceptions of Vaping Products

United States53 participantsStarted 2025-03-03

Plain-language summary

This clinical trial studies the effects, appeal, and abuse liability of 6-methyl nicotine (metatine) electronic cigarettes among young adults.

Who can participate

Age range

21 Years – 34 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Aged 21-34 years * Current nicotine EC user (defined as ≥ weekly use over the past 3 months) * Willing to provide informed consent and abstain from using any e-cigarette at least 12 hours prior to the three lab sessions * Read and speak English Exclusion Criteria: * Recently coronavirus disease 2019 (COVID-19) positive (defined as a positive test in the past 30 days) or a recent COVID-19 hospitalization (defined as a hospitalization within the past 6 months) * Unstable or significant psychiatric conditions (past and stable conditions will be allowed) * History of cardiac event or distress within the past 3 months * Have suffered from any serious lung disease or infection (e.g., tuberculosis, cystic fibrosis, or lung cancer) in the past 30 days * Are currently pregnant, planning to become pregnant, or breastfeeding (will be verified with urine pregnancy test) * Have hemophilia or another type of bleeding disorder * Are blind, severely visually impaired, deaf, hard of hearing, or have a severe motor disability

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Pharmacokinetics of metatine and nicotine e-cigarettes

Timeframe: Pre-vaping session, Minute 5 of vaping session, Minute 15 of vaping session, Minute 30 of vaping session

E-cigarette puffing behavior

Timeframe: Week 1, Week 2, Week 3

Sensory perceptions of EC vaping experience

Timeframe: Minute 5 of vaping session, Minute 30 of vaping session

Appeal ratings

Timeframe: Minute 5 of vaping session, Minute 30 of vaping session

Sensory ratings

Timeframe: Minute 5 of vaping session, Minute 30 of vaping session

Relief of withdrawal symptoms

Timeframe: Pre-vaping session, Minute 5 of Vaping Session, Minute 30 of vaping session

Trial details

NCT IDNCT06868368

SponsorOhio State University Comprehensive Cancer Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-11-04

View on ClinicalTrials.gov More Abuse Tobacco trials

Who can participate

Age range

21 Years – 34 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Pharmacokinetics of metatine and nicotine e-cigarettes

Timeframe: Pre-vaping session, Minute 5 of vaping session, Minute 15 of vaping session, Minute 30 of vaping session

E-cigarette puffing behavior

Timeframe: Week 1, Week 2, Week 3

Sensory perceptions of EC vaping experience

Timeframe: Minute 5 of vaping session, Minute 30 of vaping session

Appeal ratings

Timeframe: Minute 5 of vaping session, Minute 30 of vaping session

Sensory ratings

Timeframe: Minute 5 of vaping session, Minute 30 of vaping session

Relief of withdrawal symptoms

Timeframe: Pre-vaping session, Minute 5 of Vaping Session, Minute 30 of vaping session