The goal of this study is to perform a comprehensive analysis of varied health markers and analyze the impact of lifestyle interventions on the prognosis of anorexia nervosa (AN) patients. In addition, this study aims to determine if biomarker analysis can be used as clinical outcomes for disease prognosis long-term and support individualized treatment strategies in female patients with AN during the post-hospitalization phase. The main questions it aims to answer are: * What are the miRs and microbiota profiles associated with AN, and how are they linked to other clinical markers? * How does a lifestyle intervention (exercise with nutritional support) affect biomarkers and clinical markers during the first three months after hospitalization? * What are the dynamics and associations of biomarkers, including gut microbiota, and how do they relate to critical events during the six months after hospitalization? * What is the perceived effect of participating in a healthy lifestyle program for patients, families, and professionals involved in the care of these patients? Participants will: * Undergo analysis of biomarkers and gut microbiota associated with AN. * Participate in a lifestyle intervention program involving exercise during the first three months post-hospitalization. * Provide samples for biomarker and gut microbiota mapping over a six-month period. * Share feedback on their perceived experience in the lifestyle program through interviews or surveys. Researchers will compare biomarker and gut microbiota and the effects of the intervention to determine if a lifestyle exercise intervention can lead to better outcomes, and analyze its potential to individualized care strategies.
Age range
14 Years
Sex
ALL
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Change of microRNA profile from baseline to week 12 and week 24
Timeframe: Baseline, week 12 and week 24
Change of gut microbiota profile from baseline to week 12 and week 24
Timeframe: Baseline, week 12 and week 24
Change of Eating Disorders Examination Questionnaire (EDE-Q) scores from baseline to week 12 and week 24
Timeframe: Baseline, week 12 and week 24
Change of muscle strength from baseline to week 12 and week 24
Timeframe: Baseline, week 12 and week 24
Change of muscle content from baseline to week 12 and week 24
Timeframe: Baseline, week 12 and week 24