CompletedPhase 2

A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension (KARDINAL)

United States206 participantsStarted 2025-04-10

Plain-language summary

The purpose of this study is to evaluate the blood pressure (BP)-lowering efficacy of tonlamarsen in adult participants who, despite taking 2 or more antihypertensive medications, have not achieved their target blood pressure (BP).

Who can participate

Age range18 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Key Inclusion Criteria: * Age 18 to 80, body weight ≥ 50 kg * Has uncontrolled hypertension while receiving between 2 and 5 antihypertensive medications prescribed for hypertension * Has mean office seated systolic blood pressure \> 135 to ≤ 170 mmHg Key Exclusion Criteria: * Has known history of secondary hypertension * Has documented history of poor adherence to antihypertensive medication * Has unstable/underlying known cardiovascular disease * Has abnormal thyroid function with clinical significance

What they're measuring

To assess the effect of tonlamarsen on plasma angiotensinogen (AGT) levels

Timeframe: Week 20

To assess the systolic blood pressure-lowering efficacy of tonlamarsen

Timeframe: Week 20

Trial details

NCT IDNCT06864104

SponsorKardigan, Inc.

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2026-01-12

View on ClinicalTrials.gov More Hypertension trials