RecruitingNot Applicable

Brain and Behavior Influences on Obesity Development From Infancy Through Childhood

United States210 participantsStarted 2024-12-02

Plain-language summary

The investigators project, RESONATE, aims to investigate why some children develop obesity. To do this it uses data on eating and eating-related behaviors, genetic and environmental factors, and brain structure and function. This data is collected in a sub-sample of RESONANCE, a large study of families of children from infancy through childhood. The results will lay foundations for the development of early interventions to prevent or treat obesity.

Who can participate

Age range7 Years – 12 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Exclusion criteria

✕. In utero exposure to alcohol, cigarette, or illicit substances;
✕. First trimester fetal US abnormalities;
✕. Complicated pregnancy (e.g., pre-eclampsia);
✕. Complicated delivery, including APGAR scores less than 8 and/or neonatal intensive care unit (NICU) admission;
✕. History of neurological (e.g., epilepsy), psychiatric (e.g., anxiety or depression requiring treatment with medication) or developmental disorder (e.g., autism spectrum disorder (ASD), dyslexia);
✕. Contraindications for MRI including metal in the body, claustrophobia.

What they're measuring

Meal test intake as assessed by total kilocalories consumed

Timeframe: Day 1

Weight/adiposity as assessed by BMI

Timeframe: Day 1

Food-related reward as assessed by food-related delay discounting task

Timeframe: Day 1

Food-related cognitive control as assessed by food-related go/no-go task

Timeframe: Day 1

Functioning in brain appetite circuits as assessed by cue reactivity task

Timeframe: During MRI procedure

Functioning in brain appetite circuits as assessed by cognitive control task

Timeframe: During MRI procedure

Trial details

NCT IDNCT06861868

SponsorJohns Hopkins University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2029-03-31

Contact for this trial

Susan Carnell, PhD

410-955-7192 susan.carnell@jhmi.edu

View on ClinicalTrials.gov More Obesity and Overweight trials

Plain-language summary

Who can participate

Age range7 Years – 12 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Exclusion criteria

✕. In utero exposure to alcohol, cigarette, or illicit substances;
✕. First trimester fetal US abnormalities;
✕. Complicated pregnancy (e.g., pre-eclampsia);
✕. Complicated delivery, including APGAR scores less than 8 and/or neonatal intensive care unit (NICU) admission;
✕. History of neurological (e.g., epilepsy), psychiatric (e.g., anxiety or depression requiring treatment with medication) or developmental disorder (e.g., autism spectrum disorder (ASD), dyslexia);
✕. Contraindications for MRI including metal in the body, claustrophobia.

What they're measuring

Meal test intake as assessed by total kilocalories consumed

Timeframe: Day 1

Weight/adiposity as assessed by BMI

Timeframe: Day 1

Food-related reward as assessed by food-related delay discounting task

Timeframe: Day 1

Food-related cognitive control as assessed by food-related go/no-go task

Timeframe: Day 1

Functioning in brain appetite circuits as assessed by cue reactivity task

Timeframe: During MRI procedure

Functioning in brain appetite circuits as assessed by cognitive control task

Timeframe: During MRI procedure