Brain and Behavior Influences on Obesity Development From Infancy Through Childhood (NCT06861868) | Clinical Trial Compass
RecruitingNot Applicable
Brain and Behavior Influences on Obesity Development From Infancy Through Childhood
United States210 participantsStarted 2024-12-02
Plain-language summary
The investigators project, RESONATE, aims to investigate why some children develop obesity. To do this it uses data on eating and eating-related behaviors, genetic and environmental factors, and brain structure and function. This data is collected in a sub-sample of RESONANCE, a large study of families of children from infancy through childhood. The results will lay foundations for the development of early interventions to prevent or treat obesity.
Who can participate
Age range
7 Years – 12 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Exclusion criteria
. In utero exposure to alcohol, cigarette, or illicit substances;
. First trimester fetal US abnormalities;
. Complicated pregnancy (e.g., pre-eclampsia);
. Complicated delivery, including APGAR scores less than 8 and/or neonatal intensive care unit (NICU) admission;
. History of neurological (e.g., epilepsy), psychiatric (e.g., anxiety or depression requiring treatment with medication) or developmental disorder (e.g., autism spectrum disorder (ASD), dyslexia);
. Contraindications for MRI including metal in the body, claustrophobia.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Meal test intake as assessed by total kilocalories consumed
Timeframe: Day 1
2
Weight/adiposity as assessed by BMI
Timeframe: Day 1
3
Food-related reward as assessed by food-related delay discounting task
Timeframe: Day 1
4
Food-related cognitive control as assessed by food-related go/no-go task
Timeframe: Day 1
5
Functioning in brain appetite circuits as assessed by cue reactivity task
Timeframe: During MRI procedure
6
Functioning in brain appetite circuits as assessed by cognitive control task