The goal of this observational study is to compare laboratory and ultrasound findings between letrozole-resistant and letrozole-sensitive PCOS patients in Egypt. The study will include women aged 18-40 years diagnosed with PCOS based on the Rotterdam criteria, who are undergoing ovulation induction with letrozole for the first time. The main questions it aims to answer are: What are the baseline laboratory and ultrasound differences between letrozole-resistant and letrozole-sensitive PCOS patients? What factors can predict letrozole resistance in PCOS patients? Researchers will compare letrozole-resistant and letrozole-sensitive PCOS patients to determine whether specific laboratory markers and ultrasound findings can predict resistance to letrozole. Participants will: Undergo baseline clinical, laboratory, and ultrasound assessments before starting letrozole treatment. Receive letrozole treatment with dose escalation up to 7.5 mg/day over a maximum of three cycles if ovulation is not achieved. Be monitored through serial transvaginal ultrasounds to assess follicular development. Have ovulation confirmed via mid-luteal serum progesterone levels. The study aims to improve the understanding of predictors of letrozole resistance to guide personalized ovulation induction strategies in PCOS patients.
Age range
18 Years – 40 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Comparison of baseline FSH level between letrozole-sensitive and letrozole-resistant PCOS patients.
Timeframe: At the end of cycle 3 of treatment (each cycle is 28 days).
Comparison of baseline LH level between letrozole-sensitive and letrozole-resistant PCOS patients.
Timeframe: At the end of cycle 3 of treatment (each cycle is 28 days).
Comparison of baseline LH/FSH ratio level between letrozole-sensitive and letrozole-resistant PCOS patients.
Timeframe: At the end of cycle 3 of treatment (each cycle is 28 days).
Comparison of baseline AMH level between letrozole-sensitive and letrozole-resistant PCOS patients.
Timeframe: At the end of cycle 3 of treatment (each cycle is 28 days).
Comparison of baseline total testosterone level between letrozole-sensitive and letrozole-resistant PCOS patients.
Timeframe: At the end of cycle 3 of treatment (each cycle is 28 days).
Comparison of baseline fasting insulin level between letrozole-sensitive and letrozole-resistant PCOS patients.
Timeframe: At the end of cycle 3 of treatment (each cycle is 28 days).
Comparison of baseline glucose level between letrozole-sensitive and letrozole-resistant PCOS patients.
Timeframe: At the end of cycle 3 of treatment (each cycle is 28 days).
Comparison of baseline lipid profile between letrozole-sensitive and letrozole-resistant PCOS patients.
Timeframe: At the end of cycle 3 of treatment (each cycle is 28 days).
Comparison of baseline antral follicle count between letrozole-sensitive and letrozole-resistant PCOS patients.
Timeframe: At the end of cycle 3 of treatment (each cycle is 28 days)
Comparison of baseline ovarian volume between letrozole-sensitive and letrozole-resistant PCOS patients.
Timeframe: At the end of cycle 3 of treatment (each cycle is 28 days)