Not Yet RecruitingNot Applicable

Heterogeneity of Oral Squamous Cell Carcinoma Analysis by Single Cell RNA Sequencing

France50 participantsStarted 2025-05-15

Plain-language summary

The goal of this project is to characterise the heterogeneity of all cell populations (tumour cells, stromal and immune microenvironment) present in the tumor and their normal (and leucoplasic) counterparts by scRNAseq in OSCC patients.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * I1. Male or female at least 18 years old. * I2. Patient with OSCC and undergoing surgery at the Centre Léon Bérard. * I3. Patient who has agreed to participate in this research and sign consent. * I4. Patient affiliated to a medical insurance. Exclusion Criteria: * NI1. Pregnant or nursing woman. * NI2. Contraindication to general anesthesia. * NI3. Suspicion of rare tumor of particular histology other than squamous cell carcinoma (Sarcoma...). * NI4. Patient under curatorial or guardianship or placed under the protection of justice.

What they're measuring

Characterization of the heterogeneity of all cell populations (tumour cells, stromal and immune microenvironment) present in the tumor and their normal (and leucoplasic) counterparts by scRNAseq in OSCC patients.

Timeframe: 3 years

Trial details

NCT IDNCT06861036

SponsorCentre Leon Berard

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-05-15

Contact for this trial

Philippe Zrounba, M.D.

(0)4 69 85 60 82 philippe.zrounba@lyon.unicancer.fr

View on ClinicalTrials.gov More Oral Squamous Cell Carcinomas trials