Clinical Echocardiography and S' Wave for Early Recognition of Acute Coronary Syndrome in the Eme… (NCT06860997) | Clinical Trial Compass
CompletedNot Applicable
Clinical Echocardiography and S' Wave for Early Recognition of Acute Coronary Syndrome in the Emergency Department, A Prospective Study
Belgium66 participantsStarted 2025-01-12
Plain-language summary
The goal of this prospective observational study is to assess the diagnostic accuracy of the tissue Doppler imaging (TDI) S' wave in detecting acute coronary syndrome (ACS) in adult patients presenting to the emergency department (ED) with acute chest pain. This study focuses on patients aged 18 years or older, who require continuous cardiac monitoring but do not show ST-elevation myocardial infarction (STEMI) on their initial ECG.
The main questions it aims to answer are:
* Can TDI S' wave velocity serve as an early diagnostic marker for ACS in the emergency department?
* How does the diagnostic performance of TDI S' compare with other echocardiographic markers (MAPSE, TAPSE, and diastolic parameters such as E, E', A, E/A, E/E')?
* Do demographic factors (age, sex, BMI, echogenicity) influence the diagnostic accuracy of echocardiographic parameters for ACS? If there is a comparison group: Researchers will compare TDI S' wave velocity findings with the final adjudicated diagnosis of ACS (determined after 3 months) to evaluate its sensitivity and specificity.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥18 years
* Presenting to the emergency department (ED) with acute chest pain
* No ST-elevation myocardial infarction (STEMI) on initial ECG
* Requiring continuous cardiac monitoring based on triage decision
* Able to provide informed consent (written consent required)
Exclusion Criteria:
* Known pre-existing cardiomyopathy (e.g., hypertrophic cardiomyopathy, dilated cardiomyopathy)
* Severe valvular heart disease
* Left bundle branch block (LBBB) or presence of a pacemaker
* Arrhythmias (e.g., atrial fibrillation, frequent premature ventricular contractions)
* Cardiac arrest or cardiogenic shock at presentation
* Pulmonary hypertension
* Pericardial effusion or tamponade
* Non-cardiac cause of chest pain suspected as the primary diagnosis
* Language barrier preventing informed consent (study materials available in English, French, and Dutch)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study used a specific echocardiography measurement called the Tissue Doppler S' wave to help detect acute coronary syndrome in the emergency department — is this type of imaging routinely available or used at our hospital when ACS is suspected?
2Since this trial is already completed and was measuring how accurate the S' wave test is at diagnosing ACS, do you know if the results suggest it could meaningfully add to or change what my current diagnostic workup looks like?
3This was an observational study focused on diagnosis rather than testing a new treatment — does that mean its findings would mainly affect how quickly and confidently a doctor can confirm ACS, rather than changing the treatment itself?
4Given that this study was conducted in an emergency setting, how does the S' wave measurement compare to the standard tests I'm already getting, like troponin blood tests and a regular ECG, in terms of catching ACS early?
5Are there situations specific to my case — such as my symptoms, heart history, or how quickly I came in — where a Tissue Doppler echocardiogram like the one studied here might give my care team useful information that standard tests alone might miss?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Sensitivity and Specificity of Tissue Doppler Imaging (TDI) S' Wave for Acute Coronary Syndrome (ACS) Diagnosis
Timeframe: 3 months
Trial details
NCT IDNCT06860997
SponsorCliniques universitaires Saint-Luc- Université Catholique de Louvain