RecruitingNot Applicable

The Impact of Chronic E-Cigarette Usage on Microvascular Health

United States44 participantsStarted 2023-07-14

Plain-language summary

The study is focused on investigating the mechanisms involved in microvascular health in subjects that use e-cigarettes frequently. To explore microvascular health, different techniques and compounds. For one of the tests, iontophoresis, the drug's use will be stored and handled as described by the approved IND and non-IDS plan.

Who can participate

Age range

18 Years – 29 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

e-Cig users arm Inclusion Criteria: * Between 18 and 29 years of age * Used e-cigarettes with nicotine (≥3 times/week for ≥6 months) Exclusion Criteria: * 17 years old and younger or 30 years old or older. * Former combustible tobacco user/ former smoker * Use of cigarettes for 15 days or more in the past 60 days * Use of other tobacco products (cigars, hookah, smokeless), marijuana and/or illicit or prescription drugs weekly or more frequently in the past 60 days * Evidence of cardiovascular, pulmonary, renal, hepatic, metabolic, cerebral diseases or sleep disorders * Disorder or use of medication that affects cardiopulmonary health * Evidence of pregnancy or current nursing Non e-Cig using arm Inclusion \- Between 18 and 29 years of age Exclusion * 17 years old and younger or 30 years old and older * Use of cigarettes or other tobacco products more than 50 times in their lifetime. * Evidence of cardiovascular, pulmonary, renal, hepatic, metabolic, cerebral diseases or sleep disorders * Disorder or use of medication that affects cardiopulmonary health * Evidence of pregnancy or current nursing

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1This study is looking at how chronic e-cigarette use affects blood vessel health — specifically something called endothelial dependent dilation and neurogenic response — can you explain what those measurements actually mean for my long-term health?
2Since this trial is listed as 'Phase NA,' it seems to be an observational or measurement study rather than a treatment trial — does that mean there's no experimental treatment involved, and what exactly would be done to me during the study?
3The study focuses on microvascular health in e-cigarette users — given my own e-cigarette use history, is there already enough evidence that I should be concerned about my blood vessel health, and would participating in this study actually give me any useful information about my own condition?
4Are there any risks associated with the tests being used to measure my blood vessel function, such as the endothelial dilation testing, that I should weigh before deciding whether to participate?
5Would joining this study in any way interfere with or delay other care I might need related to my e-cigarette use, or are there other established options I should consider first?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Endothelial dependent dilation

Timeframe: Participation is one week

Neurogenic response

Timeframe: Participation is one week

Trial details

NCT IDNCT06860698

SponsorVirginia Commonwealth University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-07-28

Contact for this trial

Paula Rodriguez Miguelez

(804) 396-4498 prodriguezmig@vcu.edu

View on ClinicalTrials.gov More E-Cig Use trials