Our study aims to explore the influence of dietary chromium supplementation in the form of chromium picolinate, at different doses (200 µg and 400 µg per day), on the health of pregnant women with gestational diabetes. This study will also provide more information on the safety of this type of supplementation during pregnancies complicated by gestational diabetes mellitus. The main questions it aims to answer are: * Does chromium supplementation at various doses in women with gestational diabetes mellitus truly influence their glucido-lipidic metabolism, oxidative/antioxidant balance, and inflammatory state? If so, is it beneficial or detrimental? * If this supplementation is beneficial, which dose is the most appropriate? * Do these types of supplementation have any side effects on the health of the mother and fetus? The participants will take chromium supplements for 6 weeks (supplemented groups) while the control participants will not take them (healthy and diabetic control groups). Chromium-supplemented participants will undergo a medical check-up every 02 weeks to closely monitor their health status and detect any potential side effects at an early stage. Researchers will compare the biochemical profile, oxidative stress status, and inflammation markers between chromium-supplemented and non-supplemented participants to assess the impact of this trace element. Researchers will compare the effects of chromium supplements at different doses with each other.
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Plasma chromium level (ng/dL)
Timeframe: At baseline and after six weeks
Fasting plasma glucose level (g/L)
Timeframe: At baseline and after six weeks
Plasma cholesterol level (g/L)
Timeframe: At baseline and after six weeks
Plasma triglyceride level (g/L)
Timeframe: At baseline and after six weeks
Plasma total antioxidant status (mmol/L)
Timeframe: At baseline and after six weeks
Erythrocyte glutathione peroxidase (U/g Hb)
Timeframe: At baseline and after six weeks
Erythrocyte catalase (U/g Hb)
Timeframe: At baseline and after six weeks
Hadjer SAIFI, PhD in Biological Sciences
Erythrocyte superoxide dismutase (U/g Hb)
Timeframe: At baseline and after six weeks
Plasma 8-Hydroxydeoxyguanosine (ng/mL)
Timeframe: At baseline and after six weeks
Erythrocye malondialdehyde (µm/L)
Timeframe: At baseline and after six weeks
Erythrocyte carbonyl protein (µm/L)
Timeframe: At baseline and after six weeks
Plasma tumor necrosis factor-α (pg/mL)
Timeframe: At baseline and after six weeks
Plasma interleukin-10 (pg/mL)
Timeframe: At baseline and after six weeks
Plasma insulin level (µU/mL)
Timeframe: At baseline and after six weeks