Efficacy and Safety of GTN vs. Nifedipine in Acute Anal Fissure: A Clinical Trial

Inclusion Criteria: * Participants must meet all of the following criteria to be eligible for the study: * Age 18 to 65 years (to exclude elderly patients with different treatment responses). * Diagnosis of acute anal fissure based on clinical examination (symptom duration ≤6 weeks). * Willingness to participate in the study and provide written informed consent. * Availability for follow-up visits during the study period. * No prior use of GTN or Nifedipine for anal fissure within the past one month. * Presence of at least one of following symptoms: Anal pain, Bleeding during or after defecation and Difficulty in defecation Exclusion Criteria: * Participants will be excluded if they meet any of the following criteria: * History of chronic anal fissure (\>6 weeks duration) or prior anal fissure treatment within the past month. * Pregnant or breastfeeding women. * Known allergy or hypersensitivity to Glyceryl Trinitrate (GTN) or Nifedipine ointments. * History of cardiovascular diseases or contraindications to GTN or Nifedipine (e.g., hypotension, severe heart disease). * Presence of severe systemic diseases (e.g., uncontrolled diabetes, renal failure, autoimmune disorders) or conditions that may affect wound healing or medication tolerance. * Use of other topical treatments for anal fissure within the past month. * Secondary anal fissures associated with conditions e.g crohn's disease, tuberculosis, syphilis, HIV and other systemic diseases * Previous anal surgery (includin…