DNA Methylation and the Increased Risk of Cervical Cancer Development (NCT06859151) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
DNA Methylation and the Increased Risk of Cervical Cancer Development
2,000 participantsStarted 2025-03-20
Plain-language summary
This study aims to investigate the correlation between reproductive tract microbiota and DNA methylation in cervical epithelial cells, as well as its impact on the development of cervical cancer, through a paired case-control clinical study
Who can participate
Age range
15 Years – 50 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Aged 18-50 years old, with a history of sexual activity
. HPV and TCT tests are performed concurrently in the gynecology clinic
. Those with abnormal HPV and TCT test results undergo tissue pathological testing
Exclusion criteria
. Pregnant or breastfeeding
. Patients with immunological disorders or severe autoimmune diseases, such as AIDS, SLE
. Those who have had organ transplants or are currently using immunosuppressive agents
. Use of vaginal douching within 48 hours before sample collection
. Use of vaginal probiotics within one month before sample collection
. Use of vaginal antibiotics or antifungal treatments within one month before sample collection
. History of surgery related to cervical intraepithelial neoplasia (CIN), including but not limited to conization of the cervix, LEEP procedures, etc.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Changes in DNA methylation of cervical epithelial cells
. Blood samples (avoid sampling during menstruation), insufficient remaining sample volume to support subsequent analysis needs, and samples not stored as required.