Therapeutic Effect of Proliferative Therapy (Prolotherapy) on Pain Using Injectable Hypertonic De… (NCT06859034) | Clinical Trial Compass
Not Yet RecruitingPhase 2/3
Therapeutic Effect of Proliferative Therapy (Prolotherapy) on Pain Using Injectable Hypertonic Dextrose 25% Versus Injectable Dextrose 10% in Retrodiscal Tissues in Patients With Anterior Disc Displacement With Reduction: A Randomized Clinical Trial .
24 participantsStarted 2025-03-03
Plain-language summary
prolotherapy is an injection-based treatment method used to alleviate pain, particularly musculoskeletal pain associated with chronic ligament and tendon injuries. The process involves the injection of a solution, typically containing dextrose (a sugar), saline, or other irritants, into the affected tissues. Prolotherapy is believed to stimulate healing by causing a mild inflammatory response that promotes the regeneration of ligaments, tendons, and other connective tissues. This review explores the existing literature on the therapeutic effects of prolotherapy for pain management.
Who can participate
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Exclusion criteria:
* The clinical or radiographic signs of disc displacement without reduction .
* A history of allergic reactions to any components of the injectable solution.
* Blood dyscrasias and systemtic diseases .
* Previous surgery of the affected joint.
* Infection in pre-auricular area
Inclusion criteria:
Patients should have one or more signs and symptoms of these
* Symptoms: Patients who report typical symptoms of TMJ dysfunction, such as pain, discomfort, or clicking sounds in the joint, especially when opening or closing the mouth.
* Mouth Opening: Limited range of motion or difficulty with full mouth opening .
* Clicking: Audible clicking.
* Pain: Pain or tenderness around the TMJ, often radiating to the ear, temple, or neck
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Pain Severity Measured by Numerical Rating Scale (NRS)
Timeframe: Measured at baseline, 1 month, 3 months, and 6 months after injections.
Trial details
NCT IDNCT06859034
SponsorCairo University
Sponsor typeOTHER
Study typeINTERVENTIONAL
Primary completion2025-09-03
Contact for this trial
nourhan moustafa nourhan moustafa abd el rahman hasan abo el ela, Bachelor's degree