CompletedNot Applicable

The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH

Italy29 participantsStarted 2021-06-15

Plain-language summary

The goal of this observational study is to evaluate the role of DTI-ALPS in the diagnostic and therapeutic management of NPH The main questions it aims to answer are: * Whether the glymphatic system (GS) is actually impaired in NPH * Whether DTI-ALPS index can predict the positive response to tap test (TT) and to ventriculo-peritoneal shunt (VPS) surgery. A healthy control group of patients (HC group) matched for age with the study group, will undergo MR with DTI-ALPS study

Who can participate

Age range50 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Suspected NPH patients according to the following: Inclusion Criteria: * clinical and radiological diagnosis of probable NPH according to existing guidelines * age of over 50 years Exclusion Criteria: * inability to undergo MR * diagnosis of any other neurological pathology, particularly neurodegenerative or neuroinflammatory * previous neurosurgical interventions on the brain of any type. * inability to undergo general anaesthesia

What they're measuring

Comparison between study and control group

Timeframe: 4 years

Trial details

NCT IDNCT06857136

SponsorFondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-08-31

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