Active — Not RecruitingNot Applicable

Antibiotic Exposure on Gut Microbiota and Motility Establishment in Newborns

China200 participantsStarted 2025-02-01

Plain-language summary

This prospective cohort study aims to investigate the impact of early antibiotic exposure on the establishment of gut microbiota and motility in newborns, particularly preterm infants. The study will explore the correlation between antibiotic exposure, gut microbiota colonization, and 5-hydroxytryptamine (5-HT) levels, which are critical for gastrointestinal motility. The findings may provide insights into optimizing antibiotic use and improving gastrointestinal health in neonates.

Who can participate

Age range24 Weeks – 36 Weeks

SexALL

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Inclusion Criteria: * Newborns admitted within 72 hours of birth * Gestational age 24-36 weeks (preterm) and term infants * Informed consent obtained from parents or guardian Exclusion Criteria: * Congenital gastrointestinal malformations (e.g., intestinal atresia, Hirschsprung's disease) * Severe systemic or organ-specific diseases * Expected mortality due to severe illness

What they're measuring

gut microbiota

Timeframe: Enrollment Period: This is the time during which participants will be recruited and enrolled into the study. You have specified that enrollment will occur from November 2024 to November 2027. Intervention Period: Since this is an observational study, the

Trial details

NCT IDNCT06850896

SponsorThe First Hospital of Jilin University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-05-30

View on ClinicalTrials.gov More NEC - Necrotizing Enterocolitis trials