Active — Not RecruitingPhase 4

Comparison of Oxcarbazepine Versus Carbamazepine in the Management of Trigeminal Neuralgia

Pakistan122 participantsStarted 2024-09-21

Plain-language summary

Trigeminal neuralgia is a debilitating neurological condition, affecting quality of life in most affected patients. Carbamazepine has traditionally been used for the management of this condition, but it has a moderate effectiveness and a poor side-effect profile. Oxcarbazepine is more tolerable, and has a more favorable side-effect profile. This study aims to compare the effectiveness of oxcarbazepine and carbamazepine in the management of this condition, for improved prescription practices in the future.

Who can participate

Age range25 Years – 80 Years

SexALL

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Inclusion Criteria: * Patients of either gender (male or female) * Patients of age 25-80 years * Patients presenting with trigeminal neuralgia of any frequency and severity (according to operational definition) for six months * Patients not already receiving carbamazepine or oxcarbazepine for the management of trigeminal neuralgia Exclusion Criteria: * Patients who have undergone any surgical procedure for the treatment of trigeminal neuralgia * Patients with renal and hepatic issue such as chronic renal failure and chronic liver disease * Patients not already receiving carbamazepine or oxcarbazepine for the management of trigeminal neuralgia * Patients with seizures * Patients who are intolerant to and allergic to both treatment drugs (oxcarbazepine and carbamazepine) * Pregnant and Iactating mothers * Patients who are not willing to participate in the study

What they're measuring

Improvement in pain scores

Timeframe: 6 months

Trial details

NCT IDNCT06849219

SponsorJinnah Postgraduate Medical Centre

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2025-01-30