RecruitingNot Applicable

Mechanisms of Uterine Fluid Absorption During Early Pregnancy ( ELF Study)

United States140 participantsStarted 2025-02-01

Plain-language summary

The researchers are evaluating mechanisms of uterine fluid absorption during early pregnancy

Age range18 Years – 45 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Subject must be a healthy woman between the ages of 18 and 45 years.
✓. Women with diagnosed endometriosis or infertility (cases).
✓. Women without a diagnosis of endometriosis or infertility (controls).
✓. Subject must have regular menstrual cycles.
✓. Subject must have a body mass index (BMI) between 18 and 40.
✓. Subject must be or have been sexually active or have had a previous vaginal exam that used a speculum.
✓. Subject must be able to understand and provide consent to procedures and use/disclosure of protected health information.
✓. No history of Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, hepatitis B, and HIV.

✕. Pregnant women.
✕. Study subjects with endometrial cancer.
✕. Study subjects with a history of endometrial ablation.
✕. Study subjects with undiagnosed uterine bleeding.
✕. Women with reproductive diseases that affect the endometrium (such as fibroids or uterine polyps that distort endometrial cavity).
✕. Study subjects with an intrauterine device (IUD).

Expression levels of selected ion channels in human endometrium biopsies across the menstrual cycle.

Timeframe: 5 years

NCT IDNCT06847685

SponsorJohns Hopkins University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2029-02-01

James Segars, MD