Effect of an Early Time Restricted Eating Mediterranean Diet Compared to Naltrexone/Bupropion on Liver Fibrosis in People With Cardiometabolic Risk Factors in a Hospital Outpatient Clinic (MEDFAST-study)

Inclusion Criteria: * BMI \> 30 kg/m2 or BMI \> 27 kg/m2 and at least one cardiometabolic risk factor (T2D, hypertension, dyslipidaemia) * Moderate to severe liver fibrosis, measured as liver stiffness by transient elastography (LSM \> 7.0 kPa and \< 13.6 kPa) * Aged 18-75 years * Written informed consent Exclusion Criteria: * An insufficient comprehension of the Dutch language (spoken and written) * Female who is pregnant, breast-feeding or intends to become pregnant * Participants with an established diagnosis of liver pathology like, but not limited to: Hepatitis B, Hepatitis C, Autoimmune hepatitis, Wilson's disease, Hemochromatosis, Primary biliary cholangitis, Primary sclerosing cholangitis, Alcoholic liver disease * History of liver transplant, or current placement on a liver transplant list * History of cirrhosis and/or hepatic decompensation, including ascites, hepatic encephalopathy or variceal bleeding * Participants with active HIV infection and/or treatment * Participants with diagnosed malignancies with or without active treatment * Participants with history or pre-existing renal disease (eGFR \<30 mL/min/1.73 m2) * Participants with corticosteroid induced diabetes (while still using corticosteroids) * Participants using GLP-1 agonists for less than 3 months or not yet on a stable dose * Participants using MAO-inhibitors, opioids and/or methadone (due to contraindication) * Known or suspected excessive alcohol consumption (\>30 grams/day for males or \>20 gra…