Randomized Clinical Trial to Evaluate the Effect of Dapagliflozin in Patients With Diabetic Macular Edema

Inclusion criteria: * Type II diabetes mellitus patients, treated with premixed insulin and metformin, and diagnosed with center-involved diabetic macular edema (CiDME) * Presence of retinal thickening involving the center of the fovea (CiDME) in the study eye on Optical Coherence Tomography (OCT) Heidelberg Spectralis; If both eyes are eligible, the eye with the greater central subfield thickness on OCT is selected as the study eye. * Decreased visual acuity primarily attributable to DME * Clear ocular media and pupillary dilation for adequate retinal imaging * Ability to understand the study procedures and willingness to provide written informed consent Study participant exclusion criteria: * Patients below 18 years old and patients above 85 years old * Patients with type I diabetes mellitus (Insulin dependent diabetes mellitus IDDM) * Pregnant women and lactating women diagnosed with diabetes or intending to become pregnant in the next 12 months * Patients who had myocardial infarction within 3 months prior to screening * Patients who had transient ischemic attack (TIA), ischemic or hemorrhagic stroke within 3 months prior to screening * Patients with poorly controlled diabetes mellitus, defined as patients having glycosylated hemoglobin (HbA1c) level of ≥12% at screening or patients who were hospitalized for diabetic ketoacidosis or hyperosmolar coma within 4 months prior to screening * Patients with estimated glomerular filtration rate (eGFR) \< 30 mL/min/1.73 m2 at s…