Adaptive and Trained Immunity in the Pathogenesis of IgG4-Related Disease (NCT06844864) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Adaptive and Trained Immunity in the Pathogenesis of IgG4-Related Disease
Italy20 participantsStarted 2025-03-01
Plain-language summary
Enquire involvement of trained immunity in the pathogenesis of IgG4RD
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Patients:
* Adult subjects \> or = 18 years of age
* Subjects capable of providing informed consent
* Active IgG4-RD based on the IgG4-related disease activity index
* Fulfillment of the 2019 ACR/EULAR Classification Criteria for IgG4RD
Healthy Controls:
* Adult subjects \> or = 18 years of age
* Subjects capable of providing informed consent
Exclusion Criteria:
Patients and healthy controls:
* Subjects \< 18 years of age
* Pregnant women
* Comorbidities (other ongoing active autoimmune diseases, ongoing cancer, ongoing infections)
* Ongoing immunosuppressive therapy
What they're measuring
1
Concentration of collagen Ia in the supernant of macrophage/fibroblast co-cultures