The goal of this clinical trial is to learn whether learning and belief updating change in response to the treatment of persecutory delusions, in individuals with schizophrenia-spectrum disorders. The main questions are: 1. do prior expectations about environmental volatility reduce following effective psychotherapeutic treatment of delusions? 2. does corresponding brain activity related to volatility change with effective treatment of delusions? Participants will: 1. engage in CBTp or TAU + phone check-ins for 16 weeks 2. complete assessments at 4 timepoints over the course of 6 months 3. complete an MRI when possible
Age range
18 Years – 65 Years
Sex
ALL
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Change in prior expectations of volatility (mu3)
Timeframe: Baseline to 16 weeks
Change in unexpected uncertainty (kappa)
Timeframe: Baseline to 16 weeks
Change in psychotic Symptom Rating Scale (PSYRATS)- Belief Subscale Total
Timeframe: Baseline to 16 weeks
Change in PANSS Positive Symptoms - Total
Timeframe: Baseline to 16 weeks
BOLD activation change during PRL task, pre/post treatment - prefrontal cortex
Timeframe: Baseline to 16 weeks
BOLD activation change pre/post treatment - striatum
Timeframe: Baseline to 16 weeks
BOLD activation change during PRL task, pre/post treatment - locus coeruleus
Timeframe: Baseline to 16 weeks
Task-based functional connectivity changes during PRL task, pre/post treatment - prefrontal cortex to striatum
Timeframe: Baseline to 16 weeks