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Impact of Structural and Microenvironmental Abnormalities in Olfactory Cleft on Olfaction in CRS

China80 participantsStarted 2025-03-14

Plain-language summary

The purpose of this research is to investigate the impact of structural abnormalities and microenvironmental changes in the olfactory cleft on olfactory function in patients with chronic rhinosinusitis (CRS). It sought to elucidate the complex relationships among structural abnormalities, microenvironmental changes, and inflammatory factors contributing to olfactory dysfunction through a multidimensional assessment encompassing imaging, aerodynamics, biomarker , and histopathology analysis.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion criteria

✓. Diagnosed with CRS based on the diagnostic criteria of the EPOS guideline.
✓. Provision of signed and dated informed consent form.
✓. Patients with CRS admitted to the hospital awaiting endoscopic sinus surgery.
✓. Healthy controls undergoing surgery for the deviated septum.
✓. Provision of signed and dated informed consent form.

Exclusion criteria

✕. Those who have taken oral glucocorticoids, antibiotics, anti-leukotrienes, and antihistamines within four weeks.
✕. Patients who have had prior sinus surgery.
✕. Patients with fungal sinusitis, inverted papilloma, or other nasal diseases.
✕. Patients with a diagnosis of immune suppression or suspicion of malignancy that may be affecting the nose/paranasal sinuses.
✕. Patients who are mentally or physically unable to perform olfactory tests
✕. Patients with nasal polyps, sinusitis, nasal cavity tumors and other diseases.
✕. Patients with hyposmia or anosmia.
✕. Patients with diagnosed neurodegenerative disease.

What they're measuring

Sniffin Sticks Test

Timeframe: Immediately before surgery

Trial details

NCT IDNCT06834477

SponsorPeking University Third Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-03-14

Contact for this trial

Dawei Wu, MD, PhD

+86-10-13522503401 davidwuorl@163.com

View on ClinicalTrials.gov More Chronic Rhinosinusitis (CRS) trials