RecruitingNot Applicable

The Effects of Diet on Small Non-coding RNA i Sperm Cells and the Possible Effects on Reproductive Success: Diet Intervention Effects on Sperm

Sweden100 participantsStarted 2024-12-26

Plain-language summary

In this study, patients with infertility treated with IVF at the Center of Reproductive Medicine in Linköping, Sweden, will receive recipes and food according to Nordic dietary guidelines. The purpose is to investigate whether a short diet intervention is sufficient to improve sperm quality and shift the small non-coding RNA profile. In our previous study sperm showed rapid response to diet.

Who can participate

Age range23 Years – 56 Years

SexMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male (biological) partner in infertile couple, scheduled for first IVF treatment * Mature sperm cells in semen * Able to speak and read Swedish * Omnivore * Will refrain from nicotine and alcohol during intervention * Sperm sampled provided no more than 3 weeks before intervention start Exclusion Criteria: * Former or present malignant disease * Former radiotherapy in pelvic area * Former chemotherapy * Known genetic/chromosomal disorder * Food allergy

What they're measuring

Sperm RNA profile changes

Timeframe: At day at ovum pick-up

Sperm total count

Timeframe: At day of ovum pick-up

Sperm concentration

Timeframe: At day of ovum pick-up

Sperm sample analysis

Timeframe: At day of ovum pick-up

Trial details

NCT IDNCT06831292

SponsorOstergotland County Council, Sweden

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12

Contact for this trial

Susanne Liffner, M.D, Ph.D.

+46 (0)101030000 susanne.liffner@liu.se

View on ClinicalTrials.gov More Changes in sncRNA in Sperm trials