CompletedNot Applicable

Transcranial Magnetic Stimulation for Methamphetamine Use Disorder in PLWH

United States12 participantsStarted 2025-03-11

Plain-language summary

The purpose of this study is to learn more about how accelerated theta burst stimulation affects methamphetamine craving and brain activity. Theta burst stimulation is a unique transcranial magnetic stimulation (TMS) paradigm that is efficient and potent.

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults in the age group 18-65 years * Able to read and understand English * Able to provide informed consent * Diagnosed with HIV * History of current or previous Methamphetamine Use Disorder * Endorse craving for methamphetamine * Demonstrate an attentional bias for methamphetamine Exclusion Criteria: * Traumatic brain injury * h/o seizure disorder * h/o or current diagnosis of schizophrenia * intracranial metal shrapnel * previous adverse effects with TMS * sub-threshold consistency while performing behavioral tasks * lack of attentional bias to methamphetamine cues * a positive pregnancy test for female participants * abnormal brain MRI

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Cue-induced methamphetamine craving

Timeframe: Baseline and before and after each TMS session up to 4 days

Trial details

NCT IDNCT06830980

SponsorGopalkumar Rakesh

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-05-26

View on ClinicalTrials.gov More Methamphetamine Use Disorders trials

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.