Transcranial Focused Ultrasound Stimulation to Enhance Cognition in Healthy Participants

Inclusion Criteria: * Age: 18-55years * Healthy adults with no history of neurological or psychiatric disorders * Eligible to undergo a T1-weighted MRI scan for tFUS neuronavigational purposes * Ability to adhere to the tFUS study schedule and complete all assessments * Right-handed * Fluent in English * Abstinence from the use of any recreational drugs in the 48-hour period prior to taking part in the experiment. * Abstinence from consuming no more than 4 alcoholic units within the 24-hour period before participation. Exclusion Criteria: * Any current psychiatric diagnosis * Neurodevelopmental disorders; history of central nervous system disease, concussion, or other neurological sequelae; presence of tumors, seizures, meningitis, encephalitis, or any abnormal MRI findings of the brain * Use of any psychotropic medications within five half-lives before the procedure * Presence of metal implants contraindicated for MRI * History of head trauma with loss of consciousness * Calcification in sonicated parts of the brain. * Visual impairments that cannot be corrected with glasses * Inability to complete cognitive testing requirements * Active participation or plans for enrollment in other clinical trials that may impact psychosocial functioning * History of repeated substance abuse or dependence (excluding nicotine and caffeine); use of medications such as stimulants, modafinil, thyroid medication, or steroids * No skin disease on or close to the scalp. * History of seizure or…