Social Cognition Training in Individuals With Huntington's Disease (NCT06828471) | Clinical Trial Compass
RecruitingNot Applicable
Social Cognition Training in Individuals With Huntington's Disease
United States20 participantsStarted 2025-11-15
Plain-language summary
Individuals with Huntington's Disease have impaired social cognition, which is the domain of cognition that allows individuals to understand others' perspectives so that they can navigate interpersonal actions successfully (e.g., understanding someone may be sad based of their facial emotion or tone of voice and then responding in a sympathetic manner). Impaired social cognition is associated with impaired social functioning, poor psychological wellbeing and increased caregiver burden, which is known to be significant among those who care for individuals with Huntington's Disease. Computerized social cognition training has been shown to improve social cognition in individuals with schizophrenia, who, like individuals with Huntington's disease, have cognitive impairments. The investigators propose a pilot study of computerized social cognition training in individuals with Huntington's disease. This will be a feasibility study that aims to show that social cognition training in HD can be studied in preparation for a larger randomized controlled trial. The investigators hypothesize that social cognition training can improve social cognition, social functioning, and quality of life in individuals with Huntington's Disease and decrease caregiver burden among those who care for individuals with Huntington's Disease.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria for Individual with Huntington's Disease
* Diagnosed with Huntington's Disease based on genetic testing
* Must be between 18 and 65 years of age
* Native English speaker who is literate in English
* Stable psychotropic medication regimen for 4 weeks
* Must have a score of "somewhat easily" on all items in the CPQ-12
* MOCA \>18
* Completed 12 years of schooling
* Access to laptop or mobile device
* Willingness to come in person 6-12 weeks after first visit
Inclusion Criteria for Caregiver of Individual with Huntington's Disease
* Lives with patient
* Must be between 18 and 65 years of age
* Native English speaker who is literate in English
* MOCA \>26
* Willingness to come in person within 6-12 weeks after first visit
Exclusion Criteria for Individual with Huntington's Disease
* Any known neurological condition (other than Huntington's Disease).
* History of learning and/or intellectual disabilities
* Currently actively involved in any other interventional trial (i.e. have begun the intervention) or within 4 weeks of completing the final assessments of an interventional trial.
* Currently regularly completing a computerized cognitive training intervention.
* Active suicidal ideation with some intent
Exclusion Criteria for Caregiver of Individual with Huntington's Disease
* Inability to provide informed consent
* Active suicidal ideation with some intent
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Proportion of participants willing to consider study out of those who have been approached
Timeframe: 32 months
2
Number of participants who adhered and completed the study
Timeframe: 32 months
3
Ease of program on a scale of 1 to 5 with 5 being "very easy."