Immunogenicity, Safety, and Antibody Persistence of Different Immunization Strategies Against Japanese Encephalitis

Inclusion Criteria: * Healthy children aged 8 months who are permanent residents of the study area. * Legal guardians can understand the requirements and processes of the study, provide written informed consent, and comply with all procedures as required by the clinical research protocol. * Able to receive the full course of Japanese encephalitis vaccinations according to the immunization strategy in the research protocol, including receiving the primary immunization at 8 months of age and the booster immunizations at 24 months of age and 6 years of age. Exclusion Criteria: * Unable to finish the full course of primary and booster immunizations at the study area, and unable to fulfill the follow-up visits prescribed in the protocol. * Non-compliance with the vaccination strategy for each group, as stated in the protocol, regarding Japanese encephalitis vaccines with proper doses and varieties. * Allergic to any component of the study vaccine or having a history of allergic reactions to any vaccines. * Having a history of symptoms or signs of neurological diseases or other contraindications for Japanese encephalitis vaccine vaccination. * Having used immunosuppressants or blood products following birth. * Receiving other vaccines simultaneously while receiving the Japanese encephalitis vaccine of this project. * Any conditions that may interfere with the evaluation of the study, as deemed by the researcher.