Sleep TMS for Depression (NCT06824415) | Clinical Trial Compass
RecruitingNot Applicable
Sleep TMS for Depression
United States55 participantsStarted 2025-05-01
Plain-language summary
The goal of this study is to establish the feasibility, tolerability, and preliminary efficacy of sleep-state transcranial magnetic stimulation (TMS) for enhancing plasticity in depression treatment.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults ages 18-65 years
* Current Major Depressive Disorder (MDD) diagnosis
* Failed ≥1 antidepressant medication
* Moderate-to-severe depression
* Stable antidepressant medication dose for ≥ 6 weeks prior to enrollment
* Healthy control participants are adults ages 18-65 years without current MDD symptoms, not taking antidepressant or antipsychotic medications, and without major psychiatric, neurological, substance use, medical conditions affecting brain function, or TMS/MRI contraindications.
Exclusion Criteria:
* Intellectual disability
* Significant head injury/neurological disorder
* Pregnancy or postpartum
* TMS/MRI contraindications
* Active substance use/suicidal ideation
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is listed as 'Phase NA,' which often means it's an early research or feasibility study rather than a treatment trial — can you help me understand whether the goal here is to learn how sleep and TMS affect the brain, rather than to directly treat my depression, and what that means for me?
2The study is measuring brain activity using TMS-EEG after both a TMS session and after a period of NREM sleep — can you explain what these procedures would actually involve for me and whether there are any risks associated with having TMS delivered and then being monitored during sleep?
3The trial is tracking my performance on cognitive tasks like the N-back and MSIT tests — does this mean the study is focused on how sleep and TMS affect thinking and brain function rather than measuring whether my depression symptoms improve?
4Since this appears to be a research study on brain mechanisms rather than a head-to-head treatment comparison, would you recommend I pursue standard depression treatments at the same time, or instead of participating in this trial?
5Given that this trial is actively recruiting right now, what would the time commitment look like for me in terms of visits, sleep monitoring sessions, and TMS sessions, and is that realistic given my current situation?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.