in Vitro Evaluation of the Anti-fibrotic Activity of Adipose Tissu-derived Stromal Vascular Fract… (NCT06823908) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
in Vitro Evaluation of the Anti-fibrotic Activity of Adipose Tissu-derived Stromal Vascular Fraction Used as a Medicinal Treatment for Scarred Vocal Folds
18 participantsStarted 2025-04
Plain-language summary
This is a single-center, prospective study, aimed at investigating the anti-fibrotic in vitro activity of the stromal vascular fraction of patients with scarred vocal cord.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria for patients included in the CELLCORDES 2 clinical trial
* Voice Handicap Index \> 50/120
* Scarring, congenital (sulcus) or post-phonosurgery vocal cords
* Vibratory anomalies in the middle third of one or both vocal cords on stroboscopy
* A minimum of six months after the initial surgery
* Patients aged 18 to 70 years
* Good general health
* Negative pregnancy test and contraception for women of childbearing age Signature of consent for the storage and use of biological samples
Inclusion criteria for Healthy donnors:
* Liposuction surgery for aesthetic reasons
* BMI between 18 and 27
* No chronic diseases
* Non-opposition to the use of surgical waste for research purposes after freezing in a biological collection
Exclusion criteria: For all patients:
* Refusal or inability to comply with the study procedures
* Minors
* Pregnant or breastfeeding women
* Legally protected adults (under guardianship or curatorship)
* Individuals residing in a healthcare or social establishment emergency situations
* Individuals deprived of liberty
* Detainees
* Individuals not covered by a social security scheme
* Use of an experimental drug in the last three months
* Contraindication to local anesthesia
* Anticoagulant treatment
* Coagulation disorders (TP \< 65%, TCA \> 1.2)
* Premenopausal women of childbearing age without contraception
* Lack of or refusal of informed consent
Exclusion criteria for Patients in the CELLCORDES 2 clinical trial:
* Patients refusing p…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.