CompletedNot Applicable

TetraSOD® Supplementation and Skeletal Muscle Redox Gene Expression

United Kingdom15 participantsStarted 2021-11-05

Plain-language summary

Tetraselmis chuii (TetraSOD) is a marine microalgae that has been reported to improve antioxidant responses in human skeletal muscle cells treated with TetraSOD and to improve recovery from muscle damaging exercise in humans supplemented with TetraSOD. However, the effects of TetraSOD supplementation on human skeletal muscle antioxidant gene expression is less clear. This study assessed the effect of short-term TetraSOD supplementation on human skeletal muscle antioxidant gene expression in healthy adults.

Who can participate

Age range

18 Years – 40 Years

Sex

MALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy male (as determined by the Health Screening Questionnaire) * Adult (aged ≥18 and ≤40 years old) * Recreationally-active (≥2 and ≤4 exercise sessions per week) and a VO2max of ≥ 35 mL/kg/min and ≤ 65 mL/kg/min as determined from the preliminary exercise test * No known history of gastric, digestive, cardiovascular, renal disease or any other orthopaedic diseases related to motor organs * Non-smoker * Healthy body mass index (BMI; ≥18.5 and ≤24.9 kg/m2) * Not using any dietary supplements, including antioxidant and nitrate-rich supplements, currently or in the past one month * Not a heavy drinker (≤ 14 units of alcohol) on most weeks * Not using medication that may affect study measures * Not participating in other studies currently or in the past two months prior to the consenting session (visit 1) or having an intention to participate in other studies over the period of this study Exclusion Criteria: * Female * Aged \<18 and \>40 years old * Sedentary or highly trained with a respective V#O2max of \< 35 mL/kg/min and \> 65 mL/kg/min as determined from the preliminary exercise test * History of gastric, digestive, cardiovascular, renal disease or any other orthopaedic diseases related to motor organs * Smoker * Unhealthy body mass index (BMI;\<18.5 and \>24.9 kg/m2) * Using any dietary supplements, including antioxidant and nitrate-rich supplements, currently or in the past one month * Heavy drinker (\> 14 units of alcohol) on most weeks * Usin…

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Redox and antioxidant gene expression

Timeframe: The primary outcome will be assessed at the end of the 14 day placebo and 14 day Tetraselmis chuii supplementation arms

Trial details

NCT IDNCT06822556

SponsorLoughborough University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-08-03

View on ClinicalTrials.gov More Placebo trials