The European Bifurcation Club Randomized Trial of Stepwise Provisional Stenting Versus Drug Coated Balloon Therapy for Non-left Main True Coronary Bifurcations

Inclusion Criteria: * True non-left main bifurcation disease with both MV and SB involvement (i.e Medina 1/1/1, 1/0/1, 0/1/1) * Bifurcation lesion responsible for an acute or chronic coronary syndrome with at least one of the following: * ≥70% angiographic MV and SB diameter stenosis * Positive non-invasive testing for ischaemia * Positive coronary physiology for ischaemia * Significant SB as described by diameter stenosis ≥50% and all of the following: * SB length ≥73mm * SB diameter ≥2.5mm * Absence of another SB emerging distally from the MV * Non-dominant circumflex artery, if SB is a diagonal branch. Exclusion criteria * Patients \<18 years old * STEMI \<48 hours * Cardiogenic shock * Chronic total occlusion involving target bifurcation vessels * In-stent restenosis * Patient life expectancy \<12 months * \>2 other coronary lesions (target or non-target) planned for treatment * SYNTAX score \>32 * Platelet count ≤50x109/mm3 * Left ventricular ejection fraction ≤20% * Participation in another investigational drug or device study * Patient unable to give informed consent