RecruitingNot Applicable

Gastric Feeding Versus Transpyloric Feeding in Infants with Severe Bronchopulmonary Dysplasia, a Crossover Study

United States25 participantsStarted 2025-02-05

Plain-language summary

Hospitalized infants with severe bronchopulmonary dysplasia (BPD) and feeding intolerance will be randomized to 2 weeks of continuous gastric feeding or continuous transpyoloric feeding. Subjects will crossover after 2 weeks and receive 4 weeks of each feeding mode. Respiratory status will be assessed to determine the optimal feeding mode for each infant.

Who can participate

Age range1 Month – 1 Year

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients born \<32 weeks' gestation * Currently admitted to the Le Bonheur NICU * Grad 2 or 3 BPD (positive pressure or intubated at 36 weeks PMA) * Signs of gastroesophageal reflux, chronic aspiration, or other feeding intolerance. Exclusion Criteria: * Known gastrointestinal anomalies * Unable to tolerate ≥100mL/kg/day enteral feeding * Congenital anomalies likely to alter feeding techniques * Surgical feeding tube in place or expected within the next 8 weeks * Expected to remain hospitalized \<8 weeks

What they're measuring

Respiratory Severity Score (RSS)

Timeframe: 8 weeks

Trial details

NCT IDNCT06821776

SponsorLe Bonheur Children's Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2030-02

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