Investigating the Retardation Effect of OCTA-Guided Targeted Photocoagulation on the Progression of Non-Perfusion Areas in Diabetic Retinopathy Patients

Inclusion Criteria: * Age ≥ 18 years * Type 1 or Type 2 diabetes mellitus * Clinical dilated fundus examination and Optos imaging within 7 fields showing diabetic retinopathy (DR) lesions no more severe than severe non-proliferative diabetic retinopathy (NPDR) * Optical coherence tomography angiography (OCTA) demonstrating non-perfusion (NP) areas greater than 1 disc diameter (PD) in both eyes * Diabetic retinopathy in both eyes at the same stage, with the total NP area within the observed range of OCTA being comparable (difference less than 5 PD) * Absence of other ocular diseases that could lead to the formation of retinal microaneurysms * Absence of other ocular diseases that could lead to the formation of retinal non-perfusion areas * No diabetic macular edema involving the fovea * No history of retinal laser treatment * No history of intravitreal injection therapy within the past 3 months * No history of ocular surgery other than cataract surgery * Ability to cooperate with all examinations and provide informed consent Exclusion Criteria: * Optical media opacity affecting OCTA imaging * Patients with difficulties in cooperating with laser treatment * Patients with renal failure, diabetic neuropathy, or severe cardiovascular diseases * Patients who are unlikely to complete follow-ups every 3 months, as well as those residing in other provinces * Patients requiring early PRP (conditions include: combined DME, planned cataract surgery, pregnancy planning, early PDR, poor…