Lipomas are benign tumors composed of mature adipose tissue. While harmless, these are the most common type of soft tissue growths with some patients developing numerous lipomas. Patients often seek removal for cosmesis, or symptoms caused by location and/or compression of surrounding structures. This exploratory study aims to evaluate the effectiveness of subcutaneous injections of cooled normal saline as a treatment option for lipomas. The study will assess whether this technique could serve as a viable alternative to existing treatment options, especially compared to topically applied fat-freezing devices. The Investigators propose that this method may offer a more comfortable nonsurgical option for targeted fat reduction, as the cold temperatures are applied directly to the lipomas. Amendment to Protocol Feb 2026- Including and additional ARM of the study to evaluate the effectiveness of subcutaneous injections of warmed normal saline as a treatment option for lipomas.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Post-Injection Pain (First Treatment)
Timeframe: 15 minutes post injection (treatment)
Post-Injection Pain (Second Treatment)
Timeframe: 15 minutes post injection (treatment)
Post-Injection Pain (Third Treatment)
Timeframe: 15 minutes post injection (treatment)
Post-Injection Pain (Forth Treatment)
Timeframe: 15 minutes post injection (treatment)
Post-injection erythema (First Treatment)
Timeframe: 15 minutes post injection (treatment)
Post-injection erythema (Second Treatment)
Timeframe: 15 minutes post injection (treatment)
Post-injection erythema (Third Treatment)
Timeframe: 15 minutes post injection (treatment)
Post-injection erythema (Forth Treatment)
Timeframe: 15 minutes post injection (treatment)
Change in Lipoma Size (Second Treatment)
Timeframe: Baseline to Second Treatment (4-week interval between treatments)
Change in Lipoma Size (Third Treatment)
Timeframe: Baseline to Third Treatment (4-week interval between treatments)
Change in Lipoma Size (Forth Treatment)
Timeframe: Baseline to Forth Treatment (4-week interval between treatments)
Change in Lipoma Size (12 weeks following the Fourth Treatment)
Timeframe: From Baseline to 12 weeks following the Fourth Treatment