The participants are being asked to take part in this trial, because the participant is a survivor of childhood cancer or agreed to be part of a volunteer group to understand the relation between cancer and cancer treatment and muscle weakness in survivors of Acute Lymphoblastic Leukemia (ALL). ALL is cancer of the blood and bone marrow. Primary Objective • To compare muscle mtOXPHOS activity and satellite cell content among ALL survivors and controls. Secondary Objective * To evaluate the association between muscle mtOXPHOS, muscle satellite cell content and physical performance in ALL survivors. * To evaluate the association of muscle morphology and epigenetics with muscle mtOXPHOS in ALL survivors.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
To explore feasibility of MRI/MRS to measure OXPHOS capacity
Timeframe: Baseline
To explore feasibility of 31P-MRS to measure OXPHOS capacity
Timeframe: Baseline
To explore feasibility of 1H-MRS to measure OXPHOS capacity
Timeframe: Baseline
To explore feasibility of CrCEST MRI to measure OXPHOS capacity
Timeframe: Baseline
To explore feasibility of Fat Fraction MRI to measure OXPHOS capacity
Timeframe: Baseline
To explore feasibility of Muscle Ultrasound to measure OXPHOS capacity
Timeframe: Baseline
To explore feasibility of Muscle Biopsy to measure OXPHOS capacity
Timeframe: Baseline
To explore feasibility of mtDNA-CN to measure OXPHOS capacity
Timeframe: Baseline