CompletedPhase 4

Success of Lesion Sterilization and Tissue Repair Therapy

Turkey (Türkiye)58 participantsStarted 2022-09-14

Plain-language summary

This study aimed to assess the clinical and radiographic success of lesion sterilization and tissue repair (LSTR) therapy with different antibiotic combinations, focusing on evaluating whether the alternative combination of clindamycin instead of minocycline is as effective as the standard 3Mix-MP formulation.

Who can participate

Age range

3 Years – 10 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Spontaneous pain * Pain on percussion * The presence of abnormal or pathological mobility * The presence of a sinus tract or dentoalveolar abscess * Widening of the periodontal ligament * Periradicular radiolucency * Evidence of external and/or internal resorption. Exclusion Criteria: * Who required infective endocarditis prophylaxis * Who had used antibiotics in the two weeks prior to treatment * İndividuals allergic to the medications used in the study * Teeth with pulp floor perforation * Advanced internal and/or external root resorption * Root canal obliteration * Excessive bone loss in the furcation area involving the permanent tooth follicle * Teeth with severe coronal destruction, nonrestorable.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

clinical success

Timeframe: 12 months

radiographic success

Timeframe: 12 months

overall success

Timeframe: 12 months

Trial details

NCT IDNCT06818578

SponsorInonu University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-08-30

View on ClinicalTrials.gov More Primary Teeth trials

Plain-language summary

Who can participate

Age range

3 Years – 10 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.