By InvitationPhase 4

Comparison of Outcomes of Management of Bowel Obstruction Pilot Study

United States10 participantsStarted 2025-03-01

Plain-language summary

The Comparison of Outcomes of Management of Bowel Obstruction (COMBO Pilot) Pilot trial is a patient-level randomized trial of a short course of dexamethasone + supportive care vs supportive care alone for patients with adhesion-related small bowel obstruction (aSBO). The goal of the COMBO trial is to answer the question: Can Dexamethasone increases the proportion of patients with resolution of aSBO with non-operative management (without complication) based on an established minimal important clinical difference.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. CT findings consistent with diagnosis of SBO; and
✓. signs and symptoms consistent with SBO; and
✓. Adhesions are the likely cause of SBO (absence of incarcerated hernia, internal hernia, masses, fistula, stricture, volvulus, acute episode of inflammatory bowel disease (IBD) flare, etc.).

What they're measuring

Resolution of aSBO

Timeframe: 30 days

Trial details

NCT IDNCT06817551

SponsorUniversity of Washington

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12

View on ClinicalTrials.gov More Adhesive Small Bowel Obstruction trials