Muscle Endurance in Children With Cystic Fibrosis (NCT06812793) | Clinical Trial Compass
CompletedNot Applicable
Muscle Endurance in Children With Cystic Fibrosis
Turkey (Türkiye)48 participantsStarted 2025-02-05
Plain-language summary
Cystic fibrosis (CF) is a genetic disorder affecting exocrine glands, leading to thick, viscous secretions that damage organs such as the lungs, pancreas, and reproductive system. Respiratory failure from CF lung disease is a major cause of morbidity and mortality, with chronic inflammation and infections disrupting mucociliary clearance. This results in declining respiratory functions, muscle strength, physical inactivity, and quality of life. While some studies compare respiratory and lower extremity muscle endurance in children with CF, none have evaluated core muscle endurance. This study aims to compare respiratory muscle strength, endurance, and muscle endurance in the core and lower extremities between children with CF and healthy peers.
Who can participate
Age range
6 Years – 18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria for Children with Cystic Fibrosis
* Being between the ages of 6-18,
* Being diagnosed with Cystic Fibrosis according to the American Cystic Fibrosis Association consensus guideline,
* Having a forced expiratory volume in one second (FEV1) above 40% of the predicted value
Exclusion Criteria for Children with Cystic Fibrosis
* Not being able to cooperate with the assessment methods performed in the study
* Having an orthopedic, neurological, vestibular, etc. problem that may negatively affect the assessment methods performed in the study
* Having a history of exacerbation in the last month
* Having an organ transplantation history
* Using systemic corticosteroids
Inclusion Criteria for Healthy Children
\- Being between the ages of 6-18
Exclusion Criteria for Healthy Children
* Not being able to cooperate with the assessment methods performed in the study
* Having an orthopedic, neurological, vestibular, etc. problem that may negatively affect the assessment methods performed in the study
* Having had a respiratory tract infection in the last month
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.