Efficacy and Safety of Early Initiation of Vericiguat in Heart Failure After Acute Myocardial Infarction

Inclusion Criteria: * Age ≥ 18 years old * Undertaking revascularization for criminal coronary artery during hospitalization * Acute heart failure occurs within 14 days in hospital after STEMI or NSTEMI, meeting all of the following criteria: typical symptoms or signs of heart failure; Treatment with oral or intravenous diuretics is required; LVEF measured by echocardiography is ≤ 45%; Elevated levels of NT proBNP in patients with sinus rhythm ≥ 1000pg/ml and atrial fibrillation/flutter ≥ 1600pg/ml * eGFR ≥ 15 ml/min/1.73m2 * Informed consent has to be given in written form Exclusion Criteria: * Plan to undergo staged revascularization or if the criminal coronary artery has not been successfully opened * Severe and uncontrolled lung diseases, such as newly developed pulmonary embolism, primary pulmonary hypertension, acute exacerbation of COPD, etc * Severe liver and kidney dysfunction, Child Pugh grade C or eGFR \< 15ml/min/1.73m2 * Allergies to ACEI, ARB, ARNI, beta blockers, SGLT2i, MRA, Vericiguat, and other medications * Symptomatic hypotension or systolic blood pressure less than 90mmHg after discontinuing intravenous medication * Women in the perinatal period or those planning to conceive * Patients planning to undergo elective surgical treatment or tumor chemotherapy * Diagnosed as Takotsubo cardiomyopathy or nonobstructive acute myocardial infarction (MINOCA) * Previous diagnosis of cardiomyopathy, including but not limited to dilated cardiomyopathy, hypertrophic …