RecruitingNot Applicable

Intravenous Versus Perineural Ondansetron for Laparoscopic Sleeve Gastrectomy

Egypt170 participantsStarted 2025-02-16

Plain-language summary

This prospective randomized non-inferiority study will be conducted to compare the analgesic anti-emetic effects of intravenous ondansetron versus perineural ondansetron in patients undergoing laparoscopic sleeve gastrectomy.

Who can participate

Age range18 Years – 65 Years

SexALL

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Inclusion Criteria: * Patients of either sex * American Society Anesthesiologists physical (ASA) status II-III * age between 18-65 years old * Body mass index (BMI) \>35 kg/m2 with comorbidity or \> 40 kg/m2 -- undergoing laparoscopic sleeve gastrectomy with intraoperative surgeon performed laparoscopic paragastric autonomic neural blockade.. Exclusion Criteria: * Allergy to experimental drugs. * Known to have long QT, previous history of postoperative nausea and vomiting * Abuse of alcohol, analgesia, or sedative antidepressant drugs * Chronic pain disorders * History of previous upper gastrointestinal system surgery, those with surgery-related complications during or after surgery. * Liver or kidney failure * Performance of concomitant procedures in addition to laparoscopic sleeve gastrectomy * Anesthetic complications that may alter the postoperative management protocol.

What they're measuring

Incidence of vomiting in the early 8 hours after surgery.

Timeframe: 8 hours after surgery.

Degree of postoperative pain at 1 hour after surgery as measured by the numerical rating scale pain score.

Timeframe: 1 hour after surgery.

Trial details

NCT IDNCT06810882

SponsorTanta University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12-16

Contact for this trial

Osama M Rehab, MD

01095210806 osamarehab@med.tanta.edu.eg

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