Not Yet RecruitingNot Applicable

Sufentanil in Patients With Lower Extremity Fracture Surgery Myocardial Damage Function Study

China160 participantsStarted 2025-02-05

Plain-language summary

1. To analyze the association of different doses of opioids on myocardial injury/protection through BMP-6/SMAD pathway. 2. To observe the effect of different doses of opioids on the expression of BMP-6 in bone marrow. 3. To investigate the relationship between different doses of opioids and BMP-6 and perioperative cardiovascular adverse events in patients with lower extremity fracture surgery.

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * There were 160 patients aged 18-65 years and older who needed surgery for lower extremity fracture. * ASA grades I to III, gender is not limited. Exclusion Criteria: * Patients with acute myocardial infarction in the last 6 months, those with a history of heart failure, and those with elevated troponin levels before injury. * Old fracture * Stroke patients * Liver cirrhosis, kidney failure * Serious systemic infections, alcoholism, drug dependence * Pathological fracture * Use of glucocorticoids in the past one month * Diabetic

What they're measuring

Serum BMP6

Timeframe: Immediate postoperative measurement

Trial details

NCT IDNCT06808841

SponsorSecond Hospital of Shanxi Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-05-10

Contact for this trial

Jvan Wu, Docter

15235361727 13513520761@163.com

View on ClinicalTrials.gov More Myocardial Injury trials