Not Yet RecruitingPhase 4

Difference in Serum Estrogen Level Based on Methods of Vaginal Estrogen Application (fingertip Vs Applicator Use) in Post-menopausal Women

110 participantsStarted 2025-02-01

Plain-language summary

Study the change in serum estrogen level based on the method of vaginal cream application (applicator vs fingertip application) and Measure patient satisfaction with vaginal estrogen cream application based on the method of application using a validated patient questionnaire (Likert scale).

Who can participate

Age range

18 Years – 100 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * patients who are postmenopausal for at least 1 year (since their last menses) * patients who qualify for treatment with vaginal estrogen cream and are willing to complete the treatment * English speaking patients * patients should be able to self-apply the vaginal estrogen cream using the applicator method and the fingertip application * Patients who are surgically menopausal * Military healthcare beneficiary status Exclusion Criteria: * pre and perimenopausal women * contraindication to estrogen therapy (Deep vein thrombosis, history or active cancer) * women who are not able to self apply the vaginal estrogen cream * vaginal bleeding of unknown origin * women currently on hormone replacement therapy or vaginal estrogen therapy

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Measure the change in the level of serum estrogen in postmenopausal women based on the method of application of the estrogen cream (fingertip vs applicator use).

Timeframe: 6-8 weeks

Trial details

NCT IDNCT06808347

SponsorWalter Reed National Military Medical Center

Sponsor typeFED

Study typeINTERVENTIONAL

Primary completion2025-06-30

Contact for this trial

Sara Hamade, MD

301 400 2468 sara.j.hamade.vol@health.mil

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