Optimized Cord Blood Transplantation for the Treatment of Patients With High-risk Hematologic Malignancies Who Have Relapsed After First Allogeneic Stem Cell Transplantation

Inclusion criteria

• ✓. Patient aged 0-60 y/o at the time of consent. Adult is defined as patients 18 years of age or older at the time of consent.
• ✓. Patient must have relapsed \>100 days since first transplant.
• ✓. Diagnosis and Disease Status:
• ✓. Prior treatment:
• ✓. Karnofsky score equal or greater than 70% for patients aged 16 years and older or Lansky score equal or greater than 70% for patients less than 16 years old (See Appendix B; inpatient Leukemia service transfers without discharge are acceptable provided patient has equivalent KPS as if were outpatient).
• ✓. Renal and Liver function:
• ✓. Calculated creatinine clearance \> 50 ml/min.
• ✓. Bilirubin \< 2 mg/dL (unless benign congenital hyperbilirubinemia or hemolysis).