CompletedPhase 3

Efficacy of Ozone Therapy in Reducing Complications Following Impacted Mandibular Third-molar Surgery

Bosnia and Herzegovina20 participantsStarted 2024-12-01

Plain-language summary

The goal of this clinical trial is to learn if use of ozone works to treat complications after impacted mandibular third molar surgery. It will also learn does ozone has positive effect on wound healing and quality of life. The main questions it aims to answer are: * Does ozone reduce incidence of postoperative compliactions such as pain, swelling or reduced mouth opening after impacted mandibular third molar surgery? * Does ozone improve wound healing after impacted mandibular third molar surgery? * Does ozone have positive effect on quality of life after impacted mandibular third molar surgery? Participants will: * Receive ozone after impacted mandibular third molar surgery. * Visit the clinic 1st, 3rd, and 7th days after the intervention for checkups and tests. * Keep a diary of their symptoms.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients over 18 years * Patients with bilaterally impacted mandibular third molars classified as impaction index II B * Patients in good general health (based on the ASA classification as ASA I and ASA II). Exclusion Criteria: * Contraindications for ozone application (pregnancy, hyperthyroidism, favism, anemia, myasthenia, bleeding disorders, alcohol intoxication, myocardial infarction, pacemaker, allergy to ozone) * Patients who have used corticosteroid and antibiotic therapy in the last three months prior to inclusion in the study * Patients with signs of local inflammation in the oral cavity * Female patients during pregnancy and breastfeeding.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Postoperative complication: pain

Timeframe: 1st, 3rd, and 7th days after the intervention

Postoperative complication: trismus

Timeframe: 1st, 3rd, and 7th days after the intervention

Postoperative complication: swelling

Timeframe: 1st, 3rd, and 7th days after the intervention

Cytokine levels- wound healing

Timeframe: After surgical intervention, 3rd and 7th days after the intervention

Trial details

NCT IDNCT06802354

SponsorJelena Krunic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12-15

View on ClinicalTrials.gov More Impacted Mandibular Third Molar Extraction trials

Plain-language summary

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Postoperative complication: pain

Timeframe: 1st, 3rd, and 7th days after the intervention

Postoperative complication: trismus

Timeframe: 1st, 3rd, and 7th days after the intervention

Postoperative complication: swelling

Timeframe: 1st, 3rd, and 7th days after the intervention

Cytokine levels- wound healing

Timeframe: After surgical intervention, 3rd and 7th days after the intervention