Effect of Metyrapone on Cardiovascular Risk Factors in Patients With Adrenal Incidentalomas and Cushing's Syndrome

Inclusion Criteria: Inclusion criteria - run-in (phase 1) * Unilateral or bilateral adrenal nodules with benign features associated with thickening of the adrenal arms \>5 mm on abdominal CT scan * SCS (detected 2 times in the 6 months before run-in) defined by the absence of catabolic signs of Cushing's syndrome in association with any of these 3 conditions: * Cortisol levels after dexamethasone 1 mg test \>50 nmol/L associated with baseline ACTH \<10 pg/mL * Cortisol levels after dexamethasone 1 mg test \>50 nmol/L associated with increased nocturnal (11 pm) salivary cortisol * Cortisol levels after dexamethasone 1 mg test \>138 nmol/L * Hypertension (BP ≥140/90 mmHg and/or ongoing antihypertensive treatment) * Patients who cannot undergo surgery * Acquisition of informed consent. Inclusion criteria - randomization (phase 2) \- BP \>100/60 mmHg and \<130/85 mmHg on antihypertensive therapy (lowest effective dose) within 6-10 months after enrollment. Exclusion Criteria: * Body mass index ≥40 kg/m2 * Pregnant or lactating women; diagnosis of pregnancy will be made by serum β-HCG assay * Women of childbearing age using contraceptive measures other than barrier contraception. Barrier contraceptive measures are: o Male or female condom with or without spermicide o Cervical cup, diaphragm or sponges with spermicide o Combination of male condom and cervical cup, diaphragm or sponges with spermicide (dual barrier methods) * Treatment with steroids in the last year befo…