CompletedNot Applicable

Is There a Correlation Between Endometrial CD56 Levels and the Unfavorable KIR AA Genotype in IVF Implantation Success?

Romania80 participantsStarted 2023-08-12

Plain-language summary

This prospective observational study was conducted over 12 months and involved 80 IVF patients aged 20-40 years. Patients were divided into two groups based on KIR genotype (KIR AA and non-KIR AA). Endometrial biopsies were collected during the mid-luteal phase for immunohistochemical analysis of CD56+ NK cell levels. Statistical analyses, including logistic regression and ROC curve evaluation, assessed the relationship between CD56 levels, KIR genotype, and implantation success.

Who can participate

Age range21 Years – 40 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Female patients aged 20-40 years. * Normal uterine cavity confirmed by hysteroscopy or sonohysterography. * At least three previous failed IVF cycles or a history of recurrent pregnancy loss (RPL). Exclusion Criteria: * uterine abnormalities, * systemic autoimmune diseases, * severe male infertility factors.

What they're measuring

the relationship between endometrial CD56+ NK cells, KIR AA genotypes, and IVF success.

Timeframe: 12 months

Trial details

NCT IDNCT06795984

SponsorCalla IVF Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-08-15

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